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Abstract #25938 Published in IGR 12-2
Effect of three treatment protocols on acute ocular hypertension after phacoemulsification and aspiration of cataracts in dogs
Crasta M; Clode AB; McMullen Jr RJ; Pate DO; Gilger BCVeterinary Ophthalmology 2010; 13: 14-19
Objective To compare the effect of topical latanoprost, intracameral carbachol, or no adjunctive medical therapy on the development of acute postoperative hypertension (POH) and inflammation after routine phacoemulsification and aspiration (PA) of cataracts in dogs. Design Retrospective study. Procedures Dogs received either one drop of topical 0.005% latanoprost (21 dogs, 39 eyes), an intracameral injection of 0.3 mL of 0.01% carbachol (15 dogs, 30 eyes), or no adjunctive therapy (46 dogs, 90 eyes) immediately following PA of cataract(s). Intraocular pressure (IOP) was measured in all dogs 2 and 4 h after surgery. IOP was measured and aqueous flare assessed at 8am the day after surgery. Results Carbachol-treated dogs had significantly higher mean IOP (33.2 (plus or minus) SD 20.8 mmHg) 2 h after surgery than dogs receiving no adjunctive therapy (22.0 (plus or minus) SD 14.1 mmHg) (P = 0.049). There were no significant differences in IOP among groups at any other time point. There were no significant differences in number of POH episodes between dogs treated with carbachol (47%), latanoprost (29%), or dogs that received no adjunctive therapy (33%). There were no significant differences in mean aqueous flare grade between eyes treated with latanoprost (1.7 (plus or minus) SD 0.4) or carbachol (1.4 (plus or minus) SD 0.6), and eyes that received no adjunctive therapy (1.7 (plus or minus) SD 0.4). Conclusions Topical 0.005% latanoprost or intracameral injection of 0.3 mL of 0.01% carbachol after PA in dogs did not reduce POH or increase intraocular inflammation compared to dogs not receiving adjunctive therapy after PA of cataracts.
A. B. Clode. Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, United States. alison_clode@ncsu.edu
Classification:
5.3 Other (Part of: 5 Experimental glaucoma; animal models)
12.12.3 Phacoemulsification (Part of: 12 Surgical treatment > 12.12 Cataract extraction)
