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Abstract #26002 Published in IGR 12-2
Multiscale finite element modeling of the lamina cribrosa microarchitecture in the eye
Downs JC; Roberts MD; Burgoyne CF; Hart RTConference proceedings : Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2009; 2009: 4277-4280
In this paper, we describe a new method for constructing macro-scale models of the posterior pole of the eye to investigate the role of intraocular pressure in the development and progression of glaucoma. We also describe a method and present results from micro-scale finite element models of the lamina cribrosa microarchitecture that are derived from parent macro-scale continuum models using a novel multiscale substructuring approach. The laminar micro-scale models capture the biomechanical behavior of the laminar trabeculae in a way that cannot be estimated using macro-scale techniques, and predict much higher stresses and strains than those calculated within macro-scale models of the coincident region in the same eye.
J.C. Downs. Ocular Biomechanics Laboratory, Devers Eye Institute, 1225 NE 2nd Avenue, Portland, OR 97232, USA. cdowns@deverseye.org
Classification:
15 Miscellaneous
2.3 Sclera (Part of: 2 Anatomical structures in glaucoma)
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
