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Abstract #26190 Published in IGR 12-2
Specificity of the program threshold noiseless trend for perimetric progression analysis
de la Rosa MG; Diaz-Aleman T; Gonzalez-Hernandez M; Jerez-Fidalgo MCurrent Eye Research 2010; 35: 302-307
PURPOSE: To evaluate the specificity of the Threshold Noiseless Trend program (TNT), designed to measure progression in visual fields, using four procedures. MATERIALS AND METHODS: A. In 63 eyes with ocular hypertension, whose last examination showed no perimetric or morphological defects, we performed a mean of 7.70 +/- 1.71 follow-up examinations during 2.2 +/- 0.6 years. B. In 81 glaucomatous eyes examined twice with a bracketing strategy (Octopus 1-2-3 perimeter), we calculated mean threshold value and long-term fluctuation. We simulated 12 different visual fields, adding a random component to simulate an equivalent fluctuation of amplitude. C. Seventy-two glaucomatous eyes, with and without progression, were examined 7.76 +/- 1.25 times during 4.88 +/- 1.39 years using the Humphrey-Sita Standard strategy. Visual field tests were randomly disordered and analyzed using TNT. D. 1221 eyes were examined 7.19 +/- 3.5 times during 3.50 +/- 1.45 years (10,407 visual fields) using TOP-G1 program. We detected progression in 204 eyes using TNT. They were re-evaluated after random disordering of visual field tests. RESULTS: The four procedures indicated specificity > or = 95% as from the seventh examination; this reduced to 90% in experiment C with six examinations, and in experiments A and C with five examinations. CONCLUSIONS: The specificity of TNT may be considered to be over 95% with a large number of examinations, and 90-100% with fewer examinations. At least five examinations are required for a basic interpretation of progression, and preferably more than six to guarantee the specificity of the result.
Hospital Universitario de Canarias, Universidad de Laguna, Canary Islands, Spain.
Classification:
6.6.2 Automated (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
6.6.3 Special methods (e.g. color, contrast, SWAP etc.) (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)