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Abstract #26238 Published in IGR 12-2
Refractive error, ocular and general parameters and ophthalmic diseases. The Beijing Eye Study
Xu L; You QS; Jonas JBGraefe's Archive for Clinical and Experimental Ophthalmology 2010; 248: 721-729
OBJECTIVE: To assess relationships between refractive error and ocular and general parameters. METHODS: The Beijing Eye Study is a population-based study which included 4,439 Chinese subjects examined in 2001, with a follow-up examination in 2006, in which 3,251 (73.2%) subjects participated. RESULTS: In multivariate regression analysis, increasing (hyperopic) refractive error was significantly associated with the systemic parameters of higher age (P < 0.001), rural region (P < 0.001), lower education level (P = 0.004), higher frequency of ever smoking (P = 0.02), and higher body mass index (P = 0.02). Adjusted for the systemic parameters, increasing (hyperopic) refractive error was significantly associated with higher best-corrected visual acuity (P < 0.001), lower anterior chamber depth (P < 0.001) and narrower chamber angle (P < 0.001), lower intraocular pressure (P = 0.001), lower amount of nuclear cataract (P = 0.007), smaller beta zone of parapapillary atrophy (P < 0.001), a lower prevalence of open-angle glaucoma (P = 0.01), and a higher prevalence of age-related macular degeneration (P = 0.04). Refractive error was not significantly (P > 0.05) associated with the prevalence of trachoma, non-glaucomatous optic nerve damage, and retinal vein occlusions, nor with mortality. CONCLUSIONS: In the adult Chinese population, hyperopic subjects compared with myopic subjects were older, lived predominately in the rural regions, had a lower level of education, smoked more, and were more obese. In addition, the hyperopic subjects had a lower intraocular pressure, a higher best-corrected visual acuity, a shallower anterior chamber depth and narrower anterior chamber angle, lower amount of nuclear cataract, smaller beta zone of parapapillary atrophy, a lower prevalence of open-angle glaucoma, and a higher prevalence of age-related macular degeneration.
Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Street, Chong Wen Men, 100005 Beijing, China. xlbio@yahoo.cn
Classification:
8.1 Myopia (Part of: 8 Refractive errors in relation to glaucoma)