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Abstract #26347 Published in IGR 12-3
Optic nerve regeneration
Benowitz LI; Yin YArchives of Ophthalmology 2010; 128: 1059-1064
Retinal ganglion cells are usually not able to regenerate their axons after optic nerve injury or degenerative disorders, resulting in lifelong visual loss. This situation can be partially reversed by activating the intrinsic growth state of retinal ganglion cells, maintaining their viability, and counteracting inhibitory signals in the extracellular environment. Advances during the past few years continue to extend the amount of regeneration that can be achieved in animal models. These findings give hope that clinically meaningful regeneration may become a reality within a few years if regenerating axons can be guided to their appropriate destinations.
F.M. Kirby Neurobiology Center, Children's Hospital Boston, Department of Surgery, Harvard Medical School, Massachusetts, USA. larry.benowitz@childrens.harvard.edu
Classification:
11.8 Neuroprotection (Part of: 11 Medical treatment)
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
