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Abstract #26402 Published in IGR 12-3
Effect of pupil dilation on retinal nerve fibre layer thickness measurements and their repeatability with Cirrus HD-OCT
Savini G; Carbonelli M; Parisi V; Barboni PEye 2010; 24: 1503-1508
PurposeTo assess whether pupil dilation influences retinal nerve fibre layer (RNFL) thickness measurements provided by spectral-domain optical coherence tomography (SD-OCT) in healthy individuals.Patients and MethodsIn this observational case series, carried out in a private clinical practice, 32 eyes of 32 participants were investigated. Using Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA, USA) three individual 200 × 200 cube optic disc scans were obtained before and after pupil dilation. The RNFL thickness was the outcome measure. Coefficient of variation (COV) and test-retest variability were calculated.ResultsPupil size did not influence RNFL thickness measurements: mean values did not change in any sector (except the 9 o'clock hour) after dilation. Excellent repeatability was achieved both before and after mydriasis. In the former condition, COV ranged between 1.37% (for average RNFL) and 4.46% (for clock hour 2 RNFL) and test-retest variability between 2.17 (for temporal quadrant RNFL) and 9.18 μm (for clock hour 6 RNFL). In the latter condition, COV ranged between 1.36% (for average RNFL) and 4.48% (for clock hour 2 RNFL) and test-retest variability between 2.41 (for average RNFL) and 9.29 μm (for clock hour 6 RNFL). The repeatability was higher than that previously reported for time-domain OCT.ConclusionIn eyes with clear media highly repeatable measurements of the RNFL thickness can be obtained by SD-OCT both before and after mydriasis.
GB Bietti Eye Foundation - IRCCS, Rome, Italy.
Classification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
2.8 Iris (Part of: 2 Anatomical structures in glaucoma)
