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Abstract #26408 Published in IGR 12-3
What can eye imaging techniques reveal about undiagnosed sleep disturbances?
Uhles ML; Hinshaw KD; Muehlbach MJ; Younglove DM; Ojile JM; Powell EDSleep 2010; 33: A290-A291
Introduction: There have been several case series and prevalence studies which have documented a relationship between various eye disorders, such as glaucoma, floppy eyelid syndrome, and optic neuropathy with obstructive sleep apnea (OSA). However, there has been rea paucity of data documenting this relationship utilizing optical coherence tomography (OCT). The current study attempts to characterize the prevalence of OSA in patients with abnormal variants of OCT findings. Methods: This retrospective case series evaluated 96 consecutive patients referred for diagnostic sleep evaluation following ophthalmological evaluation. All patients had received OCT as part of their ophthalmological evaluation. Patients were between the ages of 18-79 and were not previously diagnosed with a sleep disorder. Abnormal OCT findings were defined as least one of the retinal thickness dimensions in each eye (superior, inferior, nasal, temporal) beyond the normal distribution percentiles. Results: A total of 66 patients had full OCT reports and polysomnography data available for analysis (41 abnormal OCT, 25 normal OCT). 71% of patients with abnormal OCT vs. 40% with normal OCT tested positive for sleep apnea (AHI > 5/hr; x2 = 6.068, P = 0.014). Comparison of groups indicated a higher arousal index associated with the abnormal OCT group (30.2 vs. 25.9/hr) and less Stage 3% (10.1% vs. 15.1%), although not a statistically significant difference. Conclusion: OCT is a powerful tool that allows for high resolution imaging of the optic nerve. As demonstrated in the present study, and considering the strong relationship between eye disease and poor sleep, the use of OCT may give new insight to the impact and pathophysiology associated with the consequences of poor sleep.
M.L. Uhles. Clayton Sleep Institute, St. LouisUnited States.
Classification:
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
