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Abstract #26492 Published in IGR 12-3
Changes in various immunological parameters of lacrimal fluid in excessive scarring after antiglaucoma surgery in patients with primary open-angle glaucoma
Erichev VP; Gankovskaia LV; Koval'chuk LV; Gankovskaia OA; Dugina AEVestnik Oftalmologii 2010; 126: 25-29
Twenty-two patients in whom the expression of the human beta-defensin-2 (HBD-2) gene and the concentrations of human neutrophil peptides (HNP 1-3) and interleukin-17 (IL-17) were determined in the conjunctiva and lacrimal fluid were followed. In patients with primary open-angle glaucoma, the baseline concentrations of HNP 1-3 and IL-17 in lacrimal fluid and the expression of the HBD-2 gene in the conjunctival epithelial cells were higher than those in healthy individuals. The appearance of signs of pathological scarring was observed when HBD-2 expression in the conjunctival epithelial cells was lower and the rate of changes in the lacrimal fluid concentrations of HNP 1-3 and IL-17 was stable.LA: Russian
V.P. Erichev.
Classification:
2.1 Conjunctiva (Part of: 2 Anatomical structures in glaucoma)
3.6 Cellular biology (Part of: 3 Laboratory methods)
3.7 Biochemistry (Part of: 3 Laboratory methods)
