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Abstract #26511 Published in IGR 12-3
Retinal nerve fiber layer thickness in patients with obstructive sleep apnea/hypopnea syndrome
Lin H; Lin P; Friedman M; Chang H; Pulver TMSleep 2010; 33: A130
Introduction: Obstructive sleep apnea/hypopnea syndrome (OSAHS) is characterized by recurrent intermittent hypoxemia. Any factors compromising optic nerve head perfusion and oxygenation can lead to glaucomatous optic neuropathy. Glaucomatous optic neuropathy is associated with progressive retinal nerve fiber layer (RNFL) damage. Early signs of glaucoma typically manifest as thinning of the RNFL. The purpose of this study is to determine the RNFL thickness in patients with OSAHS of different severities compared to normal controls. Methods: Subjects were recruited from among consecutive patients presenting with snoring and daytime sleepiness who underwent overnight polysomnography to determine OSAHS severity and were subsequently referred for ocular evaluation including measurement of RNFL thickness. Patients determined not to have OSAHS were included as controls. Results: A total of 127 were recruited, including 105 patients with OSAHS and 22 control subjects. Mean RNFL thickness was significantly lower for the severe OSAHS group compared to the control and mild OSAHS groups overall (P < .0001) and with respect to the superior quadrants (P = .0007). When subjects without OSAHS or with mild disease (AHI < 15) were grouped together and compared with patients with moderate to severe OSAHS (AHI (greater-than or equal to) 15), RNFL thickness measurements for the latter group were significantly lower overall (P < .0001), and in the superior (P = .001), inferior (P = .029), and temporal (P = .007) quadrants. A positive correlation was also identified between minimum oxygenation saturation on PSG and RNFL thickness overall, in the superior and nasal quadrants, and at the 1 to 5 o'clock positions (all P < 0.05). Conclusion: Compared to patients without OSAHS or those with mild disease (AHI < 15), RNFL thickness was lower in patients with moderate/ severe OSAHS. Lowest saturation of oxygen in the moderate/severe OSAHS group correlated with decreased RNFL thickness.
H. Lin. Dept. of Otolaryngology, Sleep Center, Chang Gung Memorial Hospital Kaohsiung Medical Center, KaohsiungTaiwan.
Classification:
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
