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Abstract #26532 Published in IGR 12-3
Erythropoietin is increased in aqueous humor of glaucomatous eyes
Wang Z-Y; Zhao K-K; Zhao P-QCurrent Eye Research 2010; 35: 680-684
Purpose: To determine the aqueous concentration of erythropoietin (EPO) in patients with and without glaucoma. Methods: Prospective, comparative control study. Concentrations of EPO in the aqueous humor were measured using ELISA kits from 75 patients, of whom 55 had glaucoma (14 primary acute angle-closure glaucoma, PAACG; 26 primary chronic angle-closure glaucoma, PCACG; 11 primary open-angle glaucoma, POAG; 4 neovascular glaucoma, NVG), and 20 had cataract only as control. Results: EPO concentrations in eyes with glaucoma (71.0(plus or minus)12.0 mU/mL) were significantly higher than those in eyes with cataract (6.4(plus or minus)0.8 mU/mL, P<0.001). There were no significant differences (P = 0.421) between PCACG (28.84(plus or minus)3.9 mU/mL) and POAG (20.2(plus or minus)2.0 mU/mL); however, EPO concentrations in eyes with PAACG (118.5(plus or minus)14 mU/mL) were significantly higher than these two chronic subtypes of glaucoma (P<0.001, respectively). Unusually high EPO concentrations were detected in four eyes with NVG (319.5(plus or minus)47.7 mU/mL). No effect of age, gender, different eyes, body mass index of the aqueous humor EPO concentration could be detected (P>0.05). No significant correlation was found between aqueous humor and plasma EPO concentrations in PAACG and control group (P = 0.285, 0.500, respectively). Conclusion: Our prospective study suggests that the aqueous humor EPO concentrations are increased in eyes with glaucoma.
P.-Q. Zhao. Department of Ophthalmology, Shanghai Jiaotong University, Xinhua Hospital, 1665 Kongjiang Road, Shanghai 2000092, China. zhaokekewzy@hotmail.com
Classification:
2.6.3 Compostion (Part of: 2 Anatomical structures in glaucoma > 2.6 Aqueous humor dynamics)
3.7 Biochemistry (Part of: 3 Laboratory methods)
