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Abstract #26549 Published in IGR 12-3
Phospholipases A(2) in ocular homeostasis and diseases
Wang J; Kolko MBiochimie 2010; 92: 611-619
Phospholipases A(2) (PLA(2)s) and its generation of second messengers play an important role in signal transduction, cell proliferation, cell survival and gene expression. At low concentrations mediators of PLA(2) activity have a variety of physiological effects whereas high levels of PLA(2) and its metabolites are generated during pathological conditions. The eye is an immunoprivileged organ with tight barriers and a complex interplay among various cell types. Overall, vision is a complex process which requires a clear corneal surface and lens, and thereby a clear pathway through the eye into the retina. In the retina the photoreceptors transmit light into neuronal signals that are finally transferred to the brain to perceive an image. Growing knowledge of a role of PLA(2) in ocular diseases appears and the present review aims to summarize the vast literature on PLA(2) in the normal eye as well as during pathological conditions.
M. Kolko. Department of Neuroscience and Pharmacology, Eye Pathology Section and Department of International Health, Immunology and Microbiology, University of Copenhagen, Frederik d. V's vej 11, 1st floor, 2100 Copenhagen O, Denmark. mkolko@dadlnet.dk
Classification:
3.6 Cellular biology (Part of: 3 Laboratory methods)
3.7 Biochemistry (Part of: 3 Laboratory methods)