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Abstract #26559 Published in IGR 12-3
Measurement of retinal nerve fiber layer thickness in optic atrophy eyes of patients with optic neuritis using optical coherence tomography
Wang X-L; Yu T; Xia D-Z; Zhang J-S; Yan Q-C; Luo Y-HGraefe's Archive for Clinical and Experimental Ophthalmology 2010; 248: 1013-1018
Objective: To measure the retinal nerve fiber layer (RNFL) thickness using optical coherence tomography (OCT) in optic atrophy eyes of patients with optic neuritis and investigate the correlation between the RNFL thickness and the visual function. Methods: To compare the RNFL thickness using StratusOCT, three groups of the subjects were enrolled, including 72 patients with optic atrophy with definite demyelinating optic neuritis history (the neuritis group), 47 patients with advanced POAG atrophic neuropathy (the POAG group), and 47 healthy subjects (the control group). The correlation between the RNFL thickness and visual function parameters were investigated in the neuritis group, including the best-corrected visual acuity (BCVA), the visual field mean deviation (MD), pattern standard deviation (PSD), and P100 latency of visual evoked potentials (VEP). Results: The average RNFL thickness, superior, nasal and inferior thicknesses were significantly thinner in both the neuritis group and the POAG group than those in the control group (p<0.05), while they were higher in the neuritis group than the POAG group (p<0.05). The significant correlations were found both between the average RNFL thickness and BCVA (r=0.35, p<0.05), MD (r=0.43, p<0.05), and PSD (r=0.39, p<0.05). Conclusion: In comparison to the advanced POAG and normal eyes, the RNFL thickness was decreased moderately in the optic atrophy eyes resulting from demyelinating optic neuritis and was quantitatively correlated with the visual function parameters.
X.-L. Wang. Department of Ophthalmology, China Medical University, 11 Xinhua Road, Shenyang 110005, China. wxinling@126.com
Classification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
10 Differential diagnosis e.g. anterior and posterior ischemic optic neuropathy