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Abstract #26580 Published in IGR 12-3
Levels of plasma homocysteine in pseudoexfoliation glaucoma
Tranchina L; Centofanti M; Oddone F; Tanga L; Roberti G; Liberatoscioli L; Cortese C; Manni GGraefe's Archive for Clinical and Experimental Ophthalmology 2010;
Background: To examine levels of serum homocysteine (Hcy), vitamin B12 and folic acid in patients with pseudoexfoliation glaucoma (PEXG), primary open-angle glaucoma (POAG), and healthy control subjects. Methods: This study included 36 patients with PEXG, 40 with POAG, and 40 age-matched healthy subjects. Fasting plasma Hcy concentrations and levels of serum vitamin B12 and folic acid were measured using competitive chemiluminescent enzyme immunoassay; values exceeding 14 (mu)m/l were considered elevated. Results: Mean plasma Hcy was significantly higher in PEXG (16.55 (plus or minus) 7.23 (mu)m/l) compared with POAG (13.91 (plus or minus) 3.61 (mu)m/l) and controls (13.12 (plus or minus) 5.13 (mu)m/l) (p = 0.03 and p = 0.0007 respectively). There were no statistical differences in serum vitamin B12 and folic acid levels among PEXG, POAG and control subjects (p > 0.05). A moderate, although statistically significant, relationship between Hcy and folic acid levels was found in the PEXG group (R(2) = 0.23, p = 0.003). Hcy levels were found not to be related with folic acid or vitamin B12 in either POAG or control subjects. Conclusions: In this study, plasma Hcy is significantly higher in PEXG group than the POAG and control groups. Hyper-Hcy might play a role in the pathogenesis of PEXG. Hyper-Hcy may be an independent factor stressing vasculopathy in addition to pseudoexfoliation, so might be a modifiable risk factor for PEXG.
L. Tranchina. Department of Biopathology, Ophthalmology Division, University of Rome Tor Vergata and Fondazione PTV Policlinico Tor Vergata, Via Montpellier, Rome, 1 - 00133, Italy. laura3661982@libero.it
Classification:
9.4.4.1 Exfoliation syndrome (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.4 Glaucomas associated with disorders of the lens)
3.7 Biochemistry (Part of: 3 Laboratory methods)
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
