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Abstract #26629 Published in IGR 12-3
Anti-glaucomatic niosomal system: Recent trend in ocular drug delivery research
Paul S; Mondol R; Ranjit S; Maiti SInternational Journal of Pharmacy and Pharmaceutical Sciences 2010; 2: 15-18
Glaucoma is a disease and characterized by an intraocular pressure higher than the eye can tolerate. The chronic glaucoma with open angle creates a major problem of public health and it is the second leading cause of blindness in the world. Because of the constraints of physiological factors such as lachrymal drainage, lower cul-de-sac volume, reflex tearing, drug spillage, and lower corneal permeability onto the cheek; the ocular bioavailability of conventional ophthalmic preparations is very poor. Conventional preparations require frequent instillation, and long term use of such preparations can cause ocular surface disorders. In recent years, significant efforts have been directed towards the development of new carrier systems for ocular drug delivery. Among these, non-ionic surfactant vesicles i.e. niosomes could be a potential one for the effective treatment of glaucoma patients and have gained popularity in ocular drug delivery research. This article reviews the constraints of conventional ocular therapy, complications of glaucoma therapy, and newer advances in the field of anti-glaucomatic niosomal formulation.
S. Maiti. Gupta College of Technological Sciences, Department of Pharmaceutics, Ashram More, G.T. Road, Asansol-713301, West Bengal, India. sabya245@rediffmail.com
Classification:
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
