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Abstract #26657 Published in IGR 12-3

Retinal nerve fiber layer thickness measurement by fourier-domain optical coherence tomography: A comparison between cirrus-hd oct and rtvue in healthy eyes

Savini G; Carbonelli M; Barboni P
Journal of Glaucoma 2010; 19: 369-372

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Purpose: To compare retinal nerve fiber layer (RNFL) thickness measurements by 2 Fourier-domain optical coherence tomography (OCT) instruments: Cirrus-HD OCT and RTVue. Materials And Methods: Twenty-three eyes of 23 healthy participants underwent RNFL thickness measurement using both devices on the same day. The NMH4 and Optic Disk Cube 200null200 protocols were used, respectively, for scan acquisition with RTVue and Cirrus-HD OCT. Measurements were compared by means of a paired t test. Results: RTVue gave higher mean RNFL thickness values than Cirrus-HD OCT in the superior (128.44(plus or minus)22.48 vs. 119.73(plus or minus)18.22(mu), P=0.0002), inferior (137.15(plus or minus)21.99 vs. 124.94(plus or minus)22.51(mu), P<0.0001), nasal (77.58(plus or minus)15.61 vs. 70.21(plus or minus)11.53?(mu), P=0.0009), and temporal (78.09(plus or minus)10.05 vs. 67.08(plus or minus)9.60(mu), P<0.0001) quadrants, as well as a higher 360 degrees average measurement (105.88(plus or minus)14.59 vs. 95.21(plus or minus)12.45(mu), P<0.0001). The average difference between the 2 instruments showed a standard deviation too high to calculate a reliable correcting factor for comparing a pair of individual scans taken with the 2 instruments (superior quadrant 8.70(plus or minus)9.19?(mu); inferior quadrant 13.11(plus or minus)5.4?(mu); nasal quadrant 7.37(plus or minus)9.18?(mu); temporal quadrant 11.01(plus or minus)8.50?(mu); average measurement: 10.67(plus or minus)4.88?(mu)). Conclusions: In healthy eyes RNFL measurements taken with RTVue and Cirrus-HD OCT show significant differences that make the measurements themselves noninterchangeable.

G. Savini. G.B. Bietti Eye Foundation, IRCCS, Via Livenza 3, Rome, Italy. giacomo.savini@alice.it

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Classification:

6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)

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