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Miscellaneous (18)

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Abstract #26808 Published in IGR 12-3

A genome-wide association study of optic disc parameters

Ramdas WD; van Koolwijk LME; Ikram MK; Jansonius NM; de Jong PTVM; Bergen AAB; Isaacs A; Amin N; Aulchenko YS; Wolfs RCW
PLoS Genetics 2010; 6: 1-12

See also comment(s) by Louis Pasquale •

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The optic nerve head is involved in many ophthalmic disorders, including common diseases such as myopia and open-angle glaucoma. Two of the most important parameters are the size of the optic disc area and the vertical cup-disc ratio (VCDR). Both are highly heritable but genetically largely undetermined. We performed a meta-analysis of genome-wide association (GWA) data to identify genetic variants associated with optic disc area and VCDR. The gene discovery included 7,360 unrelated individuals from the population-based Rotterdam Study I and Rotterdam Study II cohorts. These cohorts revealed two genome-wide significant loci for optic disc area, rs1192415 on chromosome 1p22 (p =6.72

J. R. Vingerling. Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands. j.vingerling@erasmusmc.nl

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Classification:

3.4.2 Gene studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)

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