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Abstract #26811 Published in IGR 12-3
A freeze-dried (lyophilized) amniotic membrane transplantation with mitomycin C and trabeculectomy for pediatric glaucoma
Mahdy RA; Nada WM; Almasalamy SM; Anany HA; Almasary AMCutaneous and Ocular Toxicology 2010; 29: 163-169
Purpose: To evaluate the potential usefulness of a freeze-dried (lyophilized) amniotic membrane transplantation with mitomycin C (MMC) in the maintenance of functioning glaucoma surgery in cases of pediatric glaucoma. Methods: Thirty eyes of pediatric patients with glaucoma were included in this study. Trabeculectomy with amniotic membrane implantation and MMC was done in group 1 (15 eyes), and trabeculectomy with MMC only was done in group 2 (15 eyes). The preserved amniotic membrane was placed over the scleral flap and under the conjunctiva. The mean intraocular pressure (IOP) was measured pre-and postoperatively and bleb appearance was noted. The follow-up time was 18 months after surgery. Results: The mean postoperative IOP was significantly decreased to 15(plus or minus)1mm Hg and 17.2(plus or minus)2.9mm Hg in the 2 groups, respectively. The bleb was functioning well in the follow-up period in most of the cases, except 5 cases that needed another surgery. Complications such as inflammation, choroidal detachment, or toxic keratopathy were not noted in group 1 but were noted in group 2. Conclusion: Trabeculectomy with amniotic membrane transplantation and MMC can effectively control the elevated IOP in pediatric patients with glaucoma without significant postoperative complications.
R. A. Mahdy. Department of Ophthalmology, Faculty of Medicine, Zagazig University, Zagazig, Sharkia, Egypt. redaelmahdy2005@yahoo.com
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
9.1.2 Juvenile glaucoma (Part of: 9 Clinical forms of glaucomas > 9.1 Developmental glaucomas)
