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Abstract #26885 Published in IGR 12-3
Impact of glaucoma medication on ocular tissue
Valente C; Iester MExpert Review of Ophthalmology 2010; 5: 405-412
Open-angle glaucoma and ocular hypertension require chronic topical treatment whose active ingredients can have some local side effects. Furthermore, different preservatives are present in the bottles to avoid contamination by common pathogens. Among all the preservatives, benzalkonium chloride is the most common and its toxic effects on the ocular tissue are well known. The purpose of this article is to investigate the ocular effects of glaucoma medication on ocular tissue, and in particular the ocular changes caused by preserved antiglaucoma drugs. Moreover, the shift from preservative-containing to preservative-free drugs, or the use of alternative preservatives with a lighter toxicity could be useful to decrease the negative impact of glaucoma medications on ocular tissues and to improve the patients compliance. The outcome of filtering surgery could change on the basis of a previous topical therapy.
M. Iester. Lab. Clin. Anatomo-Funzionale Diagnosi Trattamento Glaucoma e Delle Malat. Neurooftalmologiche, Clinica Oculistica, Department of Neurological Sciences, Viale Benedetto XV, 16132 Genova, Italy. iester@unige.it
Classification:
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)