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Abstract #26912 Published in IGR 12-3
Guangzhou twin registry and Guangzhou twin eye study
He MTwin Research and Human Genetics: the Official Journal of the International Society for Twin Studies 2010; 13: 262
The Guangzhou Twin Registry, initiated in 2005, is a populationbased registry of twins born between 1987 and 2000. To date, over 9700 pairs of twins, regardless of their health and medical history, were enrolled in the database using the Official Household Registry of Guangzhou City. The twins were subsequently verified by doorto- door visits based on the registry address. The primary goal of this registry is to develop a resource for genetic epidemiological studies on common diseases in the southern Chinese population. The initial focus is to distinguish the genetic and environmental determinants of eye diseases, in particular myopia and glaucoma. About 700 pairs of twins living close to the Zhongshan Ophthalmic Center were examined for the first phenotyping examination, questionnaire administration and DNA collection in 2006. An annual eye examination and other phenotype data collection were carried out for up to 2009 and scheduled for at least 5 years follow up in order to investigate the changes in phenotypes including the myopia progression, physical development and other general health phenotypes. Recruitment and examination of adult twins aged 50 years and over is underway in the same city. The investigation on eye diseases (Guangzhou Twin Eye Study) has produced more than 10 publications in the top Ophthalmology peer-review journals.
M. He. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou China.
Classification:
3.4.1 Linkage studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
