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Abstract #26951 Published in IGR 12-4
Effects of Propofol and Isoflurane Anesthesia on the Intraocular Pressure and Hemodynamics of Pigs.
E Buehnera; U-C Pietschb; A Bringmanna; C Fojaa; P Wiedemanna; S UhlmannaOphthalmic Research 2011; 45: 42-46
To determine the conditions under which anesthetized pigs can be used in acute noninvasive investigations of ocular hydro- and hemodynamics, the intraocular pressure (IOP) of adult pigs was recorded under the following conditions: (1) after intravenous injection of propofol plus ketamine; (2) during inhalation of isoflurane, and (3) 2 h after topical administration of bimatoprost or (4) timolol. Propofol/ketamine and isoflurane induced significant decreases in the IOP. The pulsation of the ophthalmic artery appeared at a significantly higher IOP in animals anesthetized with isoflurane than in those anesthetized with propofol/ketamine. Bimatoprost and timolol did not significantly decrease the IOP within 2 h after topical administration. It is concluded that different techniques for the acute noninvasive investigation of ocular hydro- and hemodynamics are applicable in anesthetized pigs. To test the effects of antiglaucoma agents, investigation periods longer than 2 h are required. We recommend the use of intravenous propofol/ketamine anesthesia rather than isoflurane anesthesia in future experiments using pigs.
Translational Center for Regenerative Medicine, University of Leipzig, Leipzig, Germany.
Classification:
5.3 Other (Part of: 5 Experimental glaucoma; animal models)
12.17 Anesthesia (Part of: 12 Surgical treatment)
