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Abstract #27044 Published in IGR 12-4
A study comparing ocular pressure pulse and ocular fundus pulse in dependence of axial eye length and ocular volume.
Berisha F; Findl O; Lasta M; Kiss B; Schmetterer LActa Ophthalmologica 2010; 88: 766-772
PURPOSE: There is a long-standing discussion about whether myopia is associated with decreased choroidal blood flow, as suggested by pneumotonometric measurements of pulsatile ocular blood flow (POBF). However, it has been noted previously that calculations of POBF depend on intraocular volume. METHODS: In the present study we investigated this volume dependence through the comparison of ocular pressure pulse and ocular fundus pulse. Fifty-one healthy participants with different refractive errors participated in the study. Pulse amplitude (PA) and POBF were measured using pneumotonometry. Fundus pulsation amplitude (FPA) was measured with laser interferometry. Axial eye length (AEL) was measured with partial coherence interferometry. A mathematical model was used to calculate choroidal volume changes based on FPA. The ocular pressure pulse was converted into pulse volume (PV) according to the standard procedure used for pneumotonometry. RESULTS: PA and POBF were found to decrease with increasing axial length (r = -0.55, p < 0.001 and r = -0.57, p < 0.001, respectively). A similar relationship existed for PV (r = -0.57, p < 0.001) and FPA (r = -0.46, p = 0.001). In addition, there was a significant association between PV and choroidal volume change during the cardiac cycle (r = 0.61, p < 0.001). CONCLUSION: The present study confirms experimentally that PA, FPA and POBF are dependent on ocular volume and indicates that the pulsatile component of ocular blood flow is not reduced in myopic patients. Accordingly, the relationship between AEL and POBF described previously appears to be a consequence of different ocular volumes. Our findings have important implications for studies using PA or POBF.
Department of Clinical Pharmacology, Medical University of Vienna, Austria.
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
8.1 Myopia (Part of: 8 Refractive errors in relation to glaucoma)
