advertisement
Abstract #27111 Published in IGR 12-4
Twenty-four-hour ocular perfusion pressure in primary open-angle glaucoma
Costa VP; Jimenez-Roman J; Carrasco FG; Lupinacci A; Harris ABritish Journal of Ophthalmology 2010; 94: 1291-1294
Aim: To compare the 24 h intraocular pressure (IOP), blood pressure (BP), and perfusion pressure (PP) of primary open-angle glaucoma (POAG) patients and healthy individuals. Methods: 24 healthy individuals and 29 POAG patients underwent IOP and BP measurements every 2 h, starting at 08:00 until 06:00 of the next morning. IOP measurements were made by a masked observer with a Goldmann tonometer at the slit-lamp from 08:00 to 22:00 and with the Perkins tonometer in supine position from 24:00 to 06:00. Systolic and diastolic BP (SBP and DBP) measurements were performed with an automated device. Results: Mean IOPs in POAG patients were significantly higher at all time intervals (p<0.001). The mean SBP was significantly higher in POAG patients from 04:00 to 10:00, and also at 14:00 and 18:00 (p<0.05). In POAG patients, the mean DBP was significantly higher at 08:00 and 10:00, but was significantly lower at 04:00 (p<0.05). In POAG patients, the mean systolic perfusion pressure (SPP) was significantly higher at 08:00 and 10:00 (p<0.01), whereas the mean diastolic perfusion pressure (DPP) was significantly lower from 24:00 to 06:00 (p<0.05). Conclusion Although higher SPPs are observed in POAG patients during the morning, lower DPPs are found during the night.
V. P. Costa. Department of Ophthalmology, University of Campinas, Campinas, Rua Bahia, 1087, Sao Paulo, SP 01244-001, Brazil. vp.costa@uol.com.br
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
6.1.2 Fluctuation, circadian rhythms (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
