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Abstract #27117 Published in IGR 12-4
Change in optic nerve head topography in healthy volunteers: An 11-year follow-up
Harju M; Kurvinen L; Saari J; Vesti EBritish Journal of Ophthalmology 2010;
See also comment(s) by Linda Zangwill •
Aim: To study longitudinal changes in optic nerve head (ONH) topography in healthy volunteers. Methods: One eye each of 36 healthy volunteers was prospectively followed for 11 (7-13) years with the Heidelberg Retina Tomograph I (HRT I). All eyes had normal visual fields, non-glaucomatous ONHs, no defects on red-free nerve fibre layer photographs and intraocular pressure (IOP) <22 mm Hg. During the follow-up, no eye developed glaucoma; visual fields remained normal, and no longitudinal changes appeared in nerve fibre layers assessed from red-free photographs or ONHs assessed from stereophotographs. The median baseline and follow-up IOPs were comparable (15 mm Hg, range 10-20 mm Hg; and 16 mm Hg; range 10 to 22 mm Hg, respectively; p=0.38). Images were re-evaluated with HRT III and ONHs graded as normal, borderline or glaucomatous with the Moorfield Regression Analysis (MRA). Results: Significant changes in HRT parameters indicating increased ONH cupping were detected in cup area (p=0.013), cup-to disc area ratio (p=0.015), rim area (p=0.015), mean cup depth (p=0.006) and cup shape measure (p<0.001). With the MRA classification, nine eyes (9/31, 29%) had changed for the worse in the global or any of the sector classifications. Conclusion: Age-dependent changes occur in ONH topography detectable with the HRT. Copyright Article author (or their employer) 2010.
M. Harju. Helsinki University Eye Hospital, Haartmaninkatu 4 C, PO Box 220, 00029 HUS, Helsinki, Finland. mika.harju@hus.fi
Classification:
6.9.1.1 Confocal Scanning Laser Ophthalmoscopy (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.1 Laser scanning)
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
