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Objective: To assess the relation between blue-on-yellow perimetry (B/YP) indices and optical coherence tomography (OCT) parameters in normal tension glaucoma (NTG) patients and to investigate the diagnostic ability of B/YP and OCT in discriminating NTG from normal eyes. Design: Cross-sectional study. Participants: Eighty normal subjects (80 eyes) and 80 NTG patients (80 eyes) were enrolled in the study. Methods: All patients underwent white-on-white perimetry, B/YP, and OCT measurement. The correlation between B/YP indices and OCT parameters was analyzed. The area of the receiver operating characteristic (ROC) curve was calculated to discriminate NTG patients from normal subjects. Results: A highly significant correlation was found between B/YP mean deviation (MD) and average thickness of the retinal nerve fibre layer (r(2) = 0.707, p = 0.000), and a moderately significant correlation was found between B/YPMD and temporal average (r(2) = 0.437, p = 0.010) in the earlyNTGpatients. Amildly or moderately significant correlation was found between B/YP MD and average thickness, inferior average, temporal average, superior maximum, and maximum-minimum (r(2) = 0.212-0.498, p = 0.001-0.048) in the moderate or late NTG patients. The area under the ROC curve at the B/YP MD was 0.896, and the 3 OCT parameters with the widest area under the curve were average thickness (0.957), inferior average (0.932), and superior average (0.913). Average thickness showed the highest sensitivity (93%) with specificities at 90% and 80%. Conclusions: The significant correlation between B/YP indices andOCTparameters inNTGpatients suggests that the 2 tests detect similar areas or amounts of NTG damage and could be used for NTG early diagnosis.
Y. Zhong. Department of Ophthalmology, Ruijin Hospital, Shanghai Jiaotong University, 197 Ruijin No. 2 Rd., 200025 Shanghai, China. yszhong68@yahoo.com.cn
6.6.3 Special methods (e.g. color, contrast, SWAP etc.) (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)