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Abstract #27173 Published in IGR 12-4
Skin eruption and thrombocytopaenia in a woman with glaucoma: a case report
Santos VM; Castro RA; Lima CC; Moraes MB; Sugai TAThe West Indian medical journal 2010; 59: 102-105
Antibiotic and non-antibiotic sulphonamides are often prescribed. Although chemical differences make cross-reactivity rare, reactions may be severe in patients allergic to sulphur. Adverse reactions are common with sulphonamides but low platelets and skin changes are rarely associated with eye-drops for glaucoma. A woman treated with dorzolamide and timolol presented with disseminated eruption. On admission, her physical examination was unremarkable except for the skin changes and severe thrombocytopaenia was detected. Skin biopsy showed hyperkeratosis, acanthosis, perivascular and periadnexal infiltrates with no vasculitis. After discontinuation of eye-drops, the eruption improved but low platelets persisted. Skin changes reappeared with use of dapsone which suggested sulphonamide cross-reactivity.
V.M. Santos. School of Medicine, Catholic University of Brasilia and Department of Internal Medicine, Armed Forces Hospital (HFA), Brasilia-DF, Brazil. vitorinomodesto@gmail.com
Classification:
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
