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Abstract #27180 Published in IGR 12-4
Novel association of smaller anterior chamber width with angle closure in Singaporeans
Nongpiur ME; Sakata LM; Friedman DS; He M; Chan Y-H; Lavanya R; Wong TY; Aung TOphthalmology 2010; 117: 1967-1973
Purpose: To describe variations in anterior chamber width (ACW) and investigate its association with the presence of narrow angles. Design: Cross-sectional study. Participants: We recruited 2047 subjects aged 50 years or more from a community polyclinic and 111 subjects with primary angle closure (PAC) or primary angle closure glaucoma (PACG) from an eye hospital in Singapore. Methods: All participants underwent gonioscopy, anterior chamber depth (ACD) and axial length (AL) measurement (IOLMaster; Carl Zeiss, Jena, Germany), and anterior-segment optical coherence tomography (AS-OCT, Visante, Carl Zeiss Meditec, Dublin, CA). Customized software was used to measure the ACW, defined as the distance between the scleral spurs in the horizontal (nasal-temporal) axis of AS-OCT scans. An eye was deemed to have narrow angles if the posterior trabecular meshwork was not visible for at least 180 degrees on non-indentation gonioscopy with the eye in the primary position. Main Outcome Measures: Anterior chamber width and narrow angles. Results: Data on 1465 community-based subjects were available for analysis. Anterior chamber width was significantly smaller in women compared with men (11.70 mm vs. 11.81 mm, respectively, P<0.001) and decreased significantly with age (P for trend <0.001). Significant predictors of smaller ACW were lower educational level, lower body mass index, shorter AL, shallower ACD, and Chinese race. Of the 1465 subjects, 315 (21.5%) had narrow angles on gonioscopy. Mean ACW was smaller in eyes with narrow angles compared with those without narrow angles (11.60 mm vs. 11.80 mm, P<0.001). The age- and gender-adjusted odds ratio for the highest quartile compared with the lower 3 quartiles of ACW with the presence of narrow angles was 3.4 (95% confidence interval, 2.35.0; P for trend <0.001). Hospital-based subjects with PAC/PACG had even smaller ACW than community subjects with narrow angles (11.33 mm vs. 11.60 mm, P<0.001). Conclusions: In this cross-sectional study, ACW was smaller in women, Chinese persons, and older persons, and was associated with narrow angles in 2 different study populations. These data suggest that a smaller ACW may represent a novel risk indicator for angle closure. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references. (copyright) 2010 American Academy of Ophthalmology.
T. Aung. Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751, Singapore. tin11@pacific.net.sg
Classification:
9.3.5 Primary angle closure (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
2.4 Anterior chamber angle (Part of: 2 Anatomical structures in glaucoma)
