advertisement
Abstract #27297 Published in IGR 12-4
Impact of injection techniques on intraocular pressure (IOP) increase after intravitreal ranibizumab application
Hohn F; Mirshahi AGraefe's Archive for Clinical and Experimental Ophthalmology 2010; 248: 1371-1375
Purpose: To examine the influence of different intravitreous injection techniques on the short-term intraocular pressure (IOP) in patients with exudative age-related macular degeneration (AMD) receiving 0.05 ml ranibizumab (Lucentis(registered trademark)) in the supine position. Methods: Forty-five eyes (45 patients, 16 male, 29 female, mean age: 78 years) received intravitreal ranibizumab injections for treatment of exudative AMD (0.05 ml(element of)=(element of)0.5 mg). A total of 31 patients received a standard straight scleral incision, and 14 were injected using the tunneled sclera technique. IOP was measured by Schiotz tonometry immediately pre-and postoperatively, and the amount of subconjunctival reflux was documented using a semi-quantitative scale. Twenty-three eyes were phakic, and the remaining 22 were pseudophakic. No history of glaucoma was present. The Wilcoxon matched-pairs test was used for comparisons. Results: The mean preoperative IOP was 22.4(element of)(plus or minus)(element of)5.5 mmHg in the supine position. Immediately after the injection, the IOP increased to 47.9(element of)(plus or minus)(element of)15.1 (range 23-82). The mean difference between preoperative IOP and immediately after the injection was 25. 5(element of)(plus or minus)(element of)13.6 mmHg. The mean IOP increase in eyes receiving a standard straight scleral incision was 21.9(element of)(plus or minus)(element of)14.2 mmHg (median 22.3) versus 33.5(element of)(plus or minus)(element of)7.2 mmHg (median 34.7) in the tunneled scleral incision group (p(element of)=(element of)0.001). Conclusions: IOP increased significantly in a considerable number of patients after receiving 0.05-ml intravitreal ranibizumab injections. This increase was dependent on the intravitreal injection technique and was significantly higher if a tunneled scleral injection was performed. (copyright) 2010 Springer-Verlag.
F. Hohn. Department of Ophthalmology, Ludwigshafen Hospital, Bremserstr. 79, Ludwigshafen 67063, Germany. dr.hoehn@web.de
Classification:
11.15 Other drugs in relation to glaucoma (Part of: 11 Medical treatment)
6.1.3 Factors affecting IOP (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
9.4.5.5 Other (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.5 Glaucomas associated with disorders of the retina, choroid and vitreous)
