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Abstract #27377 Published in IGR 12-4
Relief of periorbital pain after acute angle closure glaucoma attack by botulinum toxin type A
Chien K-H; Lu D-W; Chen Y-H; Cheng J-H; Chen J-TJournal of Glaucoma 2010; 19: 546-550
Purpose: To assess the efficacy and safety of botulinum toxin type A (BoNT-A) injection in patients suffering from intractable periorbital pain after acute angle closure glaucoma (AACG). Patients and Methods: In this prospective randomized intervention study, 19 patients suffering from periorbital pain after an AACG attack were injected with BoNT-A or placebo for pain relief. Patients were assessed on days 1, 2, 7, 14, 30, 60, and 90. The main outcomes were mean change of visual analog rating scale (VARS) and index scores measured through a quality-of-life questionnaire (EQ-5D), and changes in the visual analog scale (VAS), all of which were assessed at each visit. A secondary outcome was the frequency and nature of adverse events and the number of patients who withdrew from the study as a result. Results: In the treatment group (n=10), the mean index score of EQ-5D and VAS changed significantly from the placebo group (by 0.299 and 2.61, respectively) from day 2 (P<0.01). The VARS of EQ-5D also disclosed significant changes from day 2 (17, P<0.01). In addition, efficacy was maintained mainly between days 2 and 60 but declined slightly by day 90. The most frequently reported treatment-related adverse events in the treatment and placebo groups were local tenderness (21%), subcutaneous hemorrhage (10.5%), and conjunctivitis (10.5%). No severe adverse events were reported during the study or follow-up period. Conclusions: BoNT-A is effective and well tolerated for the treatment of periorbital pain after an AACG attack. Its effects may be maintained for 3 months. Copyright (copyright) 2010 by Lippincott Williams & Wilkins.
D.-W. Lu. Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, No. 325, Chenggong Road, Neihu 114, Taipei, Taiwan. p310849@ms23.hinet.net
Classification:
9.3.1 Acute primary angle closure glaucoma (pupillary block) (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
11.15 Other drugs in relation to glaucoma (Part of: 11 Medical treatment)
1.4 Quality of life (Part of: 1 General aspects)