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Abstract #27387 Published in IGR 12-4
Spectral-domain optical coherence tomography measurement of macular volume for diagnosing glaucoma
Mori S; Hangai M; Sakamoto A; Yoshimura NJournal of Glaucoma 2010; 19: 528-534
Purpose: To determine the glaucoma diagnostic power of measuring the volume of the ganglion cell complex (GCC; 3 innermost retinal layers) using spectral-domain optical coherence tomography (SD-OCT). Patients and Methods: Fifty eyes with open-angle glaucoma and 35 normal partipants were included for this study. SD-OCT (RTVue-100), and time-domain (TD)-OCT were used to measure total retinal, GCC (SD-OCT only), and circumpapillary retinal nerve fiber layer (cpRNFL) thicknesses in 50 eyes with open-angle glaucoma and in 35 without glaucoma. Results: Total retinal and GCC volumes in a macular area correlated with visual field mean deviation (GCC: r=0.580, P<0.001; total: r=0.458, P<0.001). The area under the receiver operating characteristic curve (AROC) was greater for macular GCC volume (0.922) than for macular total retinal volume, as measured by SD-OCT (0.857; P=0.020) or TD-OCT (0.841; P=0.025). GCC AROCs were smaller than cpRNFL AROCs determined using SD-OCT (0.971; P=0.110) or TD-OCT (0.970; P=0.122), but not in a statistically significant manner. AROC for the GCC was greatest in the inferior macula. Interclass correlation coefficient values were comparable for GCC and total retinal volumes. Conclusion: Selective measurement of the GCC layer by SD-OCT improves diagnostic performance of the macular structural analysis for glaucoma diagnosis. Copyright (copyright) 2010 by Lippincott Williams & Wilkins.
M. Hangai. Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shougoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan. hangai@kuhp.kyoto-u.ac.jp
Classification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)