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Abstract #27447 Published in IGR 12-4
Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve
Cafaro TA; Santo S; Robles LA; Crim N; Urrets-Zavalia JA; Serra HMMolecular Vision 2010; 16: 654-1658
Purpose: To determine levels of Peptidyl arginine deiminase 2 (PAD2) and its product protein-bound citrulline in cadaver eyes that suffered from normal tension glaucoma (NTG) compared to primary open angle glaucoma (POAG), and controls. Methods: Western analysis, ELISA, and immunohistochemical analysis were performed with human tissues. Results: We report over expression of PAD2 and higher levels of its product protein-bound citrulline in the optic nerve of normal tension glaucoma patients (NTG). Conclusions: This is the first report demonstrating that like in POAG, NTG also possesses elevated levels of both PAD2 and protein-bound citrulline. (copyright) 2010 Molecular Vision.
H. M. Serra. CIBICI, Faculty of Chemistry, National University of Cordoba, Haya de la Torre esquina Medina Allende, 5000 Cordoba, Argentina. hserra@bioclin.fcq.unc.edu.ar
Classification:
3.4.2 Gene studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
