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Abstract #27455 Published in IGR 12-4
Aqueous humor hepcidin prohormone levels in patients with primary open angle glaucoma
Sorkhabi R; Ghorbanihaghjo A; Javadzadeh A; Motlagh BF; Ahari SSMolecular Vision 2010; 16: 1832-1836
Purpose: This study was designed to evaluate the levels of Interleukin-6 (IL6) and Hepcidin prohormone (Hep) in the serum and aqueous humor of patients with primary open-angle glaucoma (POAG), as well as those with senile cataract as a control group. Methods: Levels of IL6 and Hep were measured by enzyme-linked immunosorbent assay (ELISA) methods in serum and aqueous humor aspirates taken from 45 patients (POAG=20, Control=25) during anterior segment surgery. Results: The mean aqueous humor Hep concentration in eyes with POAG was significantly higher than that controls (34.55(plus or minus)23.01 ng/ml versus 20.82(plus or minus)24.63 ng/ml, p=0.04). There was no significant difference between the serum Hep concentration of POAG and the control group (359.46(plus or minus)113.03 ng/ml versus 287.36(plus or minus)130.53 ng/ml, p=0.08). There was also no significant difference between either serum (6.18(plus or minus)5.22 versus 10.84(plus or minus)3.37, pg/ml p=0.112) or aqueous humor (4.39(plus or minus)3.06 versus 5.79(plus or minus)2.63, pg/ml p=0.14) IL6 concentrations of POAG and the control groups. No significant correlations were found between aqueous humor and serum Hep and IL6 levels in either POAG or the control groups (p>0.05). Conclusions: The aqueous humor Hep level may exist locally and independent from the IL6 increase in patients with POAG, suggesting that Hep might represent a bridge protein between local inflammation and the consequent loss of retinal ganglion cells. (copyright) 2010 Molecular Vision.
A. Ghorbanihaghjo. Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, 51664, Iran. ghorbaniamir@hotmail.com
Classification:
3.10 Immunobiology (Part of: 3 Laboratory methods)
2.6.3 Compostion (Part of: 2 Anatomical structures in glaucoma > 2.6 Aqueous humor dynamics)
3.7 Biochemistry (Part of: 3 Laboratory methods)
