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Abstract #27459 Published in IGR 12-4
The tear fluid mucin 5AC change of primary angle-closure glaucoma patients after short-term medications and phacotrabeculectomy
Liu W; Li H; Lu D; Liang J; Xing X; Liu A; Zhao S; Li X; Ji JMolecular Vision 2010; 16: 2342-2346
Purpose: This paper proposed to evaluate the tear fluid mucin 5AC (MUC5AC) change in Chinese primary angle-closure glaucoma and cataract patients after short-term medications and phacotrabeculectomy. Methods: Twenty-five eyes of 25 consecutive Chinese patients with coexisting visually significant cataract and angleclosure glaucoma and 40 eyes of 40 volunteers enrolled in this study were investigated. Tear fluid from normal subjects and patients (1 day pre-operatively, 1 month, 3 months, and 6 months post-operatively, respectively) were collected. The MUC5AC protein levels in the tear fluid were determined by Enzyme-Linked ImmunoSorbent Assay (ELISA). The MUC5AC change after phacotrabeculectomy was evaluated. Results: The MUC5AC quantity of the patients after short-term medications was 16.95(plus or minus)12.86 ng/ml, compared with 32.39(plus or minus)18.44 ng/ml MUC5AC quantity of the controls. There was a significant difference between the two groups (p<0.05). The MUC5AC of the patients decreased significantly to 6.91(plus or minus)7.11 ng/ml at 1 month after surgery (p<0.05). At 3 months after surgery, the MUC5AC recovered to 15.53(plus or minus)12.63 ng/ml, and had no significant difference with the pre-operative level (p=0.26). At 6 months after surgery, the MUC5AC was 18.94(plus or minus)14.64 ng/ml and had no significant difference with before-surgery levels (p=0.14). Conclusions: Both phacotrabeculectomy and short-term anti-glaucoma medications can decrease the MUC5AC in the tear fluid of primary angle-closure glaucoma patients. At 3 months after phacotrabeculectomy, the MUC5AC could recover to the pre-operative level. More attention should be paid to the tear film stability and ocular surface physiology in these patients. (copyright) 2010 Molecular Vision.
J. Ji. Tianjin Medical University Eye Center, 251 Fukang Road, Nankai District, Tianjin, 300384, China. tjykzx@yahoo.com.cn
Classification:
2.1 Conjunctiva (Part of: 2 Anatomical structures in glaucoma)
9.3.2 Chronic primary angle closure glaucoma (pupillary block) (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
12.14.3 Phacoemulsification (Part of: 12 Surgical treatment > 12.14 Combined cataract extraction and glaucoma surgery)
