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Abstract #27496 Published in IGR 12-4
Topical administration of adrenergic receptor pharmaceutics and nerve growth factor
Steinle JJClinical Ophthalmology 2010; 4: 605-610
Topical application of nerve growth factor (NGF) and adrenergic receptor pharmaceutics are currently in use for corneal ulcers and glaucoma. A recent interest in the neuroprotective abilities of NGF has led to a renewed interest in NGF as a therapeutic for retinal and choroidal diseases. NGF can promote cell proliferation through actions of the TrkA receptor or promote apoptosis through receptor p75(NTR). This understanding has led to novel interest in the role of NGF for diseases of the posterior eye. The role of (beta)-adrenergic receptor agonists and antagonists for treatments of glaucoma, diabetic retinopathy, and their potential mechanisms of action, are still under investigation. This review discusses the current knowledge and applications of topical NGF and adrenergic receptor drugs for ocular disease.(copyright)2010 Steinle, publisher and licensee Dove Medical Press Ltd.
J. J. Steinle. Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, 930 Madison Ave, Suite 768A, Memphis, TN 38163, United States. jsteinl1@uthsc.edu
Classification:
3.8 Pharmacology (Part of: 3 Laboratory methods)
11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)
