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Abstract #27547 Published in IGR 12-4
Fluorescein leakage of the optic disc: time course in primary open-angle glaucoma
Plange N; Kaup M; Doehmen B; Remky A; Arend KOOphthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians 2010; 30: 315-320
PURPOSE: To identify and quantify the time course of fluorescein leakage of the optic nerve head in primary open-angle glaucoma (POAG) and controls. METHODS: Twenty patients with POAG (aged 58 +/- 10 years) and 14 controls (aged 51 +/- 12 years, p = 0.07) were included in a prospective study. Fluorescein leakage of the optic disc was quantified using digital image analysis. A new leakage ratio (fluorescence of the optic disc divided by fluorescence of the surrounding retina) was defined and fluorescein leakage was quantified at 7-8, 9-10, 11-12, and 13-14 min after injection of 2.5 cc sodium fluorescein (10%). RESULTS: The fluorescein leakage exhibited a significantly different time course with higher leakage ratio values in POAG compared to controls (7-8 min: 1.24 +/- 0.32 vs 1.16 +/- 0.12; 9-10 min: 1.37 +/- 0.37 vs 1.19 +/- 0.1; 11-12 min: 1.38 +/- 0.36 vs 1.24 +/- 0.13; 13-14 min: 1.44 +/- 0.36 vs 1.27 +/- 0.13; p = 0.004). The change in optic disc fluorescence from 7-8 min to 9-10 min was significantly higher in POAG compared to controls (0.13 +/- 0.09 vs 0.03 +/- 0.07; p = 0.002). CONCLUSION: The time course of fluorescein leakage is significantly different in POAG compared to controls. This might reflect damage of the optic disc vasculature related to increased vascular permeability.
N. Plange. Department of Ophthalmology, RWTH Aachen University, Pauwelsstr. 30, 52057 Aachen, Germany. nplange@ukaachen.de
Classification:
6.10.2 Posterior segment (Part of: 6 Clinical examination methods > 6.10 Fluorescein (ICG) angiography)
