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Abstract #28111 Published in IGR 13-1
Bimatoprost versus travoprost in an egyptian population: A Hospital-based prospective, randomized study
MacKy TAJournal of Ocular Pharmacology and Therapeutics 2010; 26: 605-610
Purpose: To compare the efficacy of bimatoprost and travoprost on intraocular pressure (IOP) reduction in an Egyptian population. Methods: Patients with primary open-angle glaucoma or ocular hypertension were randomized to receive either bimatoprost 0.03% or travoprost 0.004% once daily. IOPs were measured at baseline; 2 weeks; and 1, 2, 4, and 6 months using Goldman applanation tonometery. Results: Seventy-two patients were included: 34 and 38 (P=0.142) with a baseline mean IOP=26.52(plus or minus)5.185 and 26.36(plus or minus)1.605mm Hg (P=0.629) for bimatoprost and travoprost, respectively. Both drops provided statistically significant IOP reductions from baseline at all visits (P<0.001). Bimatoprost provided greater (nonsignificant) mean IOP reductions from baseline than travoprost at each visit. Mean IOP reductions was 8.77mm Hg (33.39%) and 8.42mm Hg (31.54%) at 2 weeks (P=0.703), and 8.47mm Hg (31.61%) and 7.84mm Hg (29.50%) at 6 months (P=0.536) for bimatoprost and travoprost, respectively. IOPs at 2 weeks were (less-than or equal to)18mm Hg in 20 (58.8%) versus 19 (50%) eyes (P=0.603), and (less-than or equal to)16mm Hg in 12 (35%) versus 12 (32%) eyes (P=0.456); and at 6 months (less-than or equal to)18mm Hg in 22 (65%) versus 14 (37%) eyes (P=0.045), and (less-than or equal to)16mm Hg in 12 (35%) versus 7 (18%) eyes (P=0.037) for bimatoprost and travoprost, respectively. Ocular adverse and clinical success occurred equally with both drops. Conclusion: Both drops lowered IOP effectively but bimatoprost showed a greater non-significant reductions in mean IOP from baseline.
T. A. MacKy. Department of Ophthalmology, Kasr El Aini Hospital, Cairo University, 29th, 13th St., Apt. No. 11, Maadi, Cairo 11431, Egypt. tamermacky@gmail.com
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)