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Abstract #28128 Published in IGR 13-1
Langerhans cell histiocytosis of the uvea with neovascular glaucoma: Diagnosis by fine-needle aspiration biopsy and management with intraocular bevacizumab and brachytherapy
Shields CL; Hogarty MD; Kligman BE; Christian C; Ehya H; Shields JAJournal of AAPOS 2010; 14: 534-537
A 6-year-old boy with known multisystem Langerhans cell histiocytosis developed photophobia, conjunctival injection, iris neovascularization, and an iridociliochoroidal mass. Fine-needle aspiration biopsy revealed mononucleated and multinucleate histiocytes that demonstrated positive immunostaining for CD68 and S100 consistent with Langerhans cell histiocytosis. Management with intracameral bevacizumab (1.25 mg/0.05 mL) resolved the iris neovascularization, and plaque radiotherapy (brachytherapy) resolved the mass rapidly and completely, preserving the patient's visual acuity and preventing glaucoma during the 10-month follow-up.
C. L. Shields. Ocular Oncology Service, Wills Eye Institute, 840 Walnut Street, Philadelphia, PA 19107, United States. carol.shields@shieldsoncology.com
Classification:
9.4.5.1 Neovascular glaucoma (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.5 Glaucomas associated with disorders of the retina, choroid and vitreous)
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
11.15 Other drugs in relation to glaucoma (Part of: 11 Medical treatment)
