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Abstract #28163 Published in IGR 13-1
The effects of topical antiglaucoma on conjunctival impression cytology in malay glaucoma patients
Hoi TS; Nor MM; Hitam WHW; Jaafar H; Shatriah IInternational Medical Journal 2010; 17: 271-274
Objective: To compare the changes in conjunctiva surface morphology after the use of topical timolol maleate 0.5% and topical latanoprost 0.005% in Malay glaucoma patients. Design: A randomized clinical trial. Materials and Methods: 39 Malay patients, newly diagnosed primary open angle glaucoma, pseudoexfoliative glaucoma, normotensive glaucoma and chronic angle closure glaucoma without acute attack were randomly divided into topical timolol maleate 0.5% treated group and topical latanoprost 0.005% treated group. The conjunctival impression cytology was taken before and 3 months after the treatment was started. The parameters evaluated were epithelial cell morphology, mean goblet cell density and mean mucous granule density. The conjunctival impression cytology of the both groups was compared. Results: In both timolol maleate 0.5% and latanoprost 0.005% treated groups, there was no change in the epithelial cell morphology after three months of treatment. Within three months of therapy, both groups caused statistically significant reduction in the mean goblet cells density (p < 0.001) and mean mucous granules density (p < 0.001). There was no statistically significant difference in the mean goblet cells density (p = 0.571) and mean mucous granules density (p = 0.173) between the groups after 3 months of treatment. Conclusion: Both topical timolol maleate 0.5% and topical latanoprost 0.005% cause significant reduction in the mean goblet cells density and mean mucous granules density after 3 months treatment. However, these changes are comparable between the two groups in our glaucoma patients of Malay ethnicity.
I. Shatriah. Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. shatriah@kck.usm.my
Classification:
2.1 Conjunctiva (Part of: 2 Anatomical structures in glaucoma)
3.1 Microscopy (Part of: 3 Laboratory methods)
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
