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Abstract #3367 Published in IGR 4-2
Anterior segment dysgenesis and the developmental glaucomas are complex traits
Gould DB; John SWMHuman Molecular Genetics 2002; 11: 1185-1193
Glaucoma refers to a heterogeneous group of disorders that involve retinal ganglion cell death, optic nerve damage, and loss of visual field. Glaucoma is a leading cause of vision loss worldwide, affecting an estimated 67 million people. Elevated intraocular pressure is a major risk factor for glaucoma. Individuals with malformations of structures of the anterior segment of the eye frequently develop elevated intraocular pressure and glaucoma. In this review, the authors focus on the developmental glaucomas, the subset of glaucomas associated with anterior segment dysgenesis. To minimize overlap with other reviews in this issue and elsewhere, they highlight the complex, multifactorial nature of these diseases and recent advances using mice.
Dr. S.W.M. John, The Howard Hughes Medical Institute, The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA. swmj@jax.org
Classification:
1.2 Population genetics (Part of: 1 General aspects)
9.1 Developmental glaucomas (Part of: 9 Clinical forms of glaucomas)