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Abstract #3389 Published in IGR 4-2
Higher concentration of transforming growth factor-beta in aqueous humor of glaucomatous eyes and diabetic eyes
Ochiai Y; Ochiai HJapanese Journal of Ophthalmology 2002; 46: 249-253
PURPOSE: Diabetic retinopathy and glaucoma are the primary causes of acquired blindness. Cytokines including transforming growth factor (TGF)-β may be involved in these diseases. Therefore, the authors collected aqueous humor samples from patients with glaucoma and/or diabetes who were undergoing surgery, and determined the concentration of TGF-β. METHODS: Aqueous humor samples were collected from 80 patients (84 eyes), including 19 eyes with primary open-angle glaucoma (POAG), 22 eyes with diabetes, and 18 eyes with diabetes complicated with POAG. Twenty-five eyes with cataract served as controls. The concentration of TGF-β1 or TGF-β2 was measured by enzyme-linked immunosorbent assay. RESULTS: The concentration of TGF-β1 was less than 0.1 pg/ml in all the groups. In contrast to controls who had 1001.4 ± 444.1 pg/ml, the concentration of total TGF-β2 in the diabetes group was 1715.6 ± 882.1 pg/ml, and that in the diabetes complicated with POAG group was 1692.9 ± 361.9 pg/ml. These were significantly higher than that in controls. In contrast to the controls who had 321.2 ± 197.9 pg/ml, the concentration of mature TGF-β2 with POAG was 822.5 ± 484.4 pg/ml, and that of diabetes complicated with POAG was 1058.9 ± 648.4 pg/ml. These were significantly higher than that in the controls. The eyes with diabetes complicated with POAG also had a significantly higher concentration than the eyes with diabetes alone. CONCLUSIONS: Total TGF-β2 and mature TGF-β2 in high concentration may correlate with progression of POAG, diabetes, and diabetes complicated with POAG.
Dr. Y. Ochiai, Shin-Nagata Eye Institute, 4-2-11 Udetsuka-cho, Nagata-ku, Kobe-shi 653-0036, Japan
Classification:
1.3 Pathogenesis (Part of: 1 General aspects)
2.6 Aqueous humor dynamics (Part of: 2 Anatomical structures in glaucoma)
6.6 Visual field examination and other visual function tests (Part of: 6 Clinical examination methods)
9.2.2 Other risk factors for glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
