advertisement
Abstract #3444 Published in IGR 4-2
Effect of hyaluronic acid on intraocular pressure in rats
Benozzi J; Nahum LP; Campanelli JL; Rosenstein REInvestigative Ophthalmology and Visual Science 2002; 43: 2196-2200
PURPOSE: To study the effect of acute or chronic intracameral injection of hyaluronic acid on intraocular pressure (IOP) in rats. METHODS: Acute or chronic injections of hyaluronic acid were performed unilaterally in the rat eye's anterior chamber, while the contralateral eye was injected with saline solution. IOP was assessed daily or weekly by a tonometer in conscious rats. IOP was also assessed in both experimental groups at several intervals during the light-dark cycle. RESULTS: A single injection of hyaluronic acid induced an increase of IOP that lasted for eight days (p < 0.01), while its chronic administration for nine weeks induced a significant and sustained increase in IOP, compared with the eye injected with vehicle (p < 0.01). This hyaluronic acid-induced hypertension was significantly decreased by the application of one drop of brimonidine (0.2%), latanoprost (0.005%), or timolol (0.5%). Significant daily variations of IOP were observed in both control and hyaluronic acid-injected eyes, peaking during the dark phase (p < 0.001, ANOVA). CONCLUSIONS: These results suggest that the intracameral administration of hyaluronic acid could be a model of ocular hypertension in rats.
Dr. J. Benozzi, Laboratory of Retinal Neurochemistry and Experimental Ophthalmology, Department of Human Biochemistry, Faculty of Medicine, University of Buenos Aires-Paraguay 2155, 1121 Buenos Aires, Argentina
Classification:
5 Experimental glaucoma; animal models
