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Abstract #3478 Published in IGR 4-2
The effect of losartan potassium on choroidal hemodynamics in healthy subjects
Spicher T; Orgül S; Gugleta K; Teuchner B; Flammer JJournal of Glaucoma 2002; 11: 177-182
PURPOSE: To investigate the choroidal hemodynamic effects of losartan potassium, a specific angiotensin II subtype AT1 receptor antagonist. METHODS: In this prospective, randomized, observer-masked, open-label, placebo-controlled (lactose), two-period crossover study, the choroidal hemodynamic effects of a single oral 50-mg dose of losartan potassium were evaluated in 12 healthy subjects using choroidal laser Doppler flowmetry. RESULTS: Perfusion pressure and the choroidal laser Doppler flowmetry parameters velocity, volume, and flux did not vary significantly compared with placebo (p = 0.33, 0.31, 0.74, and 0.61, respectively). Correcting choroidal laser Doppler flowmetry parameters for perfusion pressure in a covariance analysis did not change these results. CONCLUSIONS: A single oral 50-mg dose of the angiotensin II AT1 receptor antagonist losartan potassium given does not disturb the homeostasis of ocular perfusion pressure or choroidal blood flow in young healthy subjects.
Dr. S. Orgül, University Eye Clinic, Basel P.O. Box CH-4012, Basel, Switzerland. sorgul@magnet.ch
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
11.7 Treatment of bloodflow (Part of: 11 Medical treatment)