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Abstract #3536 Published in IGR 4-2
Histopathological finding in a case of iris nevus syndrome with elevated intraocular pressure
Kawashima M; Yamazaki Y; Hamanaka TJapanese Journal of Clinical Ophthalmology 2002; 56: 813-817
A 66-year-old male presented with blurring of vision in his left eye during the previous few weeks. A similar episode of blurring of vision had occurred ten years earlier and had led to the detection of a deformed pupil and ocular hypertension. His left eye showed corneal edema, an intraocular pressure (IOP) of 29 mmHg, and numerous pigmented iris nevi. Gonioscopy showed peripheral anterior synechiae reaching the ring of Schwalbe over the whole circumference. His right eye was intact except for myopia. The endothelial cell count was 2951 right and 504 cells/mm2 left. These findings led to the diagnosis of Cogan-Reese syndrome. The left eye received trabeculectomy with mitomycin C. Histopathology of excised specimen showed infiltrated intertrabecular spaces by melanophages and extreme attenuation of Schlemm's canal. There is a high possibility that elevated IOP in this syndrome is due to invasion of melanophages into the intertrabecular spaces and to attenuation or occlusion of Schlemm's canal. LA: Japanese
Dr. M. Kawashima, Department of Ophthalmology, Nihon University School of Medicine, 30-1 Ohyaguchi-kamimachi Itabashi-ku, Tokyo 173-8610, Japan
Classification:
9.4.3.5 Other (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.3 Glaucomas associated with disorders of the iris and ciliary body)
