advertisement
Abstract #3573 Published in IGR 4-2
Use of latanoprost to reduce acute intraocular pressure rise following neodymium: YAG laser iridotomy
Liu CJ; Cheng CY; Chiang SC; Chiu AW; Chou JC; Hsu WM; Liu JHActa Ophthalmologica Scandinavica 2002; 80: 282-286
PURPOSE: To evaluate the efficacy of latanoprost in reducing acute intraocular pressure (IOP) elevation after neodymium:YAG laser iridotomy (LI). METHODS: Primary angle-closure glaucoma (PACG) eyes were randomized to receiving premedication with either latanoprost and pilocarpine or pilocarpine only before LI. Postoperative IOP changes were compared with Wilcoxon signed-ranks test using the fellow eyes of 47 patients who had one eye in each group. RESULTS: Postoperative pressure spikes were significantly lower (p = 0.010) in the latanoprost group (4.1 ± 5.0 mmHg) than in the control group (6.7 ± 7.0 mmHg). Mean elevation of IOP was less in the latanoprost group than in the control group at one hour (2.5 ± 4.8 versus 4.1 ± 4.7 mmHg, p = 0.013) and two hours (0.8 ± 5.6 versus 4.4 ± 8.1 mmHg, p = 0.003) postoperatively. Eleven eyes in the latanoprost group (23.4%) and 20 eyes in the control group (42.6%) developed a rise in IOP > or = 6 mmHg (p = 0.048). CONCLUSION: Latanoprost may reduce the pressure rise following LI in PACG eyes, but its application is limited by the late onset of effect.
Dr. C.J. Liu, Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan. jlliu@vghtpe.gov.tw
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
12.2 Laser iridotomy (Part of: 12 Surgical treatment)
