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Abstract #3575 Published in IGR 4-2
Suppression of diurnal variation of intraocular pressure by topical latanoprost
Miyoshi M; Kumano K; Yamakawa RJapanese Journal of Clinical Ophthalmology 2002; 56: 795-798
The authors evaluated the change in diurnal variation of intraocular pressure (IOP) induced by latanoprost in six eyes of three patients with primary open-angle glaucoma. None of the eyes had a history of glaucoma surgery. Each eye received latanoprost instillation once a day after discontinuing other hypotensive medications. IOP averaged 15.9 ± 1.2 mmHg before latanoprost and decreased significantly to 13.5 ± 1.5 mmHg three, five, and 15 months after switching to latanoprost (p < 0.01). The amount of IOP decrease ranged from 4.0-0.4 mmHg, average 2.4 mmHg. The diurnal variation was defined as the difference between maximum and minimum IOP between 11 measurements during a 24-hour period. It ranged from 6-13 mmHg, average 8.7 mmHg, before latanoprost. It significantly decreased to 2-5 mmHg, average 4.0 mmHg, after switching to latanoprost (p < 0.005). The difference in diurnal variation before and after latanoprost ranged from 2-8 mmHg, average 4.7 mmHg. These findings show that topical latanoprost is more effective in reducing IOP and in suppressing diurnal variation than other medications. LA: Japanese
Dr. M. Miyoshi, Department of Ophthalmology, Kurume University School of Medicine, 67 Asahi-cho, Kurume-shi 830-0011, Japan
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
