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Abstract #3576 Published in IGR 4-2
Additive intraocular pressure lowering effect of various medications with latanoprost
O'Connor DJ; Martone JF; Mead AAmerican Journal of Ophthalmology 2002; 133: 836-837
PURPOSE: To determine the additive intraocular pressure (IOP) reduction of various topical glaucoma agents used adjunctively with latanoprost. DESIGN: Retrospective interventional case series. METHODS: Retrospective evaluation of 73 eyes of 73 patients with glaucoma and inadequate IOP control on latanoprost alone. Each patient received adjunctive treatment with an additional glaucoma agent (dorzolamide, brimonidine, timolol, or other beta-blockers) for one year. RESULTS: When added to latanoprost, dorzolamide lowered IOP an additional 3.9 mmHg (19.7%, p < 0.001); beta-blockers further reduced IOP by 2.0 mmHg (12.3%, p < 0.001), and brimonidine further reduced IOP by 2.0 mmHg (9.3%, p = 0.0011). Dorzolamide dosed twice or three times daily was as effective as adjunctive therapy with latanoprost (p = 0.92). CONCLUSIONS: Adjunctive therapy with dorzolamide provided a statistically significant intraocular pressure reduction at one year in eyes that were inadequately controlled with latanoprost alone.
Dr. D.J. O'Connor, Post and O'Connor Eye Center, Plymouth, MA, USA
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)