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Abstract #3577 Published in IGR 4-2
The efficacy of latanoprost is independent of the width of the ciliary body face
Ritch R; Ishikawa H; Rothman R; Yu G; Liebmann JMJournal of Glaucoma 2002; 11: 239-243
PURPOSE: To assess the relationship between the intraocular pressure (IOP)-lowering efficacy of latanoprost 0.005% and the area of the ciliary body face exposed to the anterior chamber as assessed by ultrasound biomicroscopy. PATIENTS AND METHODS: Untreated, latanoprost-naive patients with ocular hypertension or open-angle glaucoma were enrolled in this prospective clinical trial. A radial, perpendicular ultrasound biomicroscopy image at the six-o'clock position detailing Schwalbe's line, scleral spur, and iris insertion was obtained. The distances between these structures were then measured and their relations to the IOP-lowering effect of latanoprost at one, two, three, and six months were analyzed. RESULTS: Fifty-four eyes (54 patients) were enrolled. The mean age of participants was 60.2 ± 13.9 years, and mean pretreatment intraocular pressure was 26.4 ± 3.8 mmHg. The mean IOP reduction from baseline was 7.1 mmHg (26.9%), 7.3 (27.7%), 7.8 (29.5%), and 7.7 (29.2%) at one, two, three, and six months, respectively. The mean distance between the scleral spur and the iris insertion was 0.14 ± 0.08 mm (range, 0.04-0.33 mm). There was a significant correlation between intraocular pressure reduction at one month and trabecular meshwork height, suggesting that IOP reduction was associated with increasing trabecular meshwork height (p < 0.05). No other correlation could be found regarding IOP reduction. CONCLUSIONS: Although latanoprost lowers IOP by enhancing uveoscleral outflow, its efficacy is independent of the height of the ciliary face.
Dr. R. Ritch, Department of Ophthalmology and the Biostatistics and Epidemiology Service, The New York Eye and Ear Infirmary, New York, NY 10003, USA. ritch@inx.net
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
