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Abstract #3604 Published in IGR 4-2
The efficacy of brimonidine in preventing intraocular pressure elevation in the provocative test for primary angle-closure glaucoma
Chen YF; Hung PT; Hsieh JW; Shein J; Hsiao CKJournal of Ocular Pharmacology and Therapeutics 2002; 18: 99-103
The purpose of this study was to evaluate the efficacy of 0.2% brimonidine tartrate in preventing intraocular pressure (IOP) elevation in the dark-prone provocative test for primary angle-closure glaucoma (PACG). Twenty-two eyes of 22 patients with angle-closure glaucoma were enrolled in this study. Each of the selected eyes had previously tested positive in a recent dark-prone test. One drop of 0.2% brimonidine tartrate was then instilled in each eye two hours prior to a second dark-prone test. An IOP elevation of greater than 8 mmHg was regarded as a positive result. The IOP elevation in the first dark-prone test was 11.91 ± 5.17 (range, 5.7-27.3) mmHg, while the IOP only increased 5.70 ± 2.96 (range, 2.9-12.2) mmHg in the second dark-prone test that was pre-treated with 0.2% brimonidine tartrate (p < 0.001). A significant difference was also noted in the pretest IOP (15.59 ± 3.86 mmHg versus 13.33 ± 3.65 mmHg, p = 0.008) as well as in the post-test IOP (27.62 ± 7.27 mmHg versus 19.03 ± 3.50 mmHg, p < 0.001) in the two sequential dark-prone tests. All but three of the initially positive dark-prone tests (86.46%) converted to negative tests after pre-treatment with brimonidine. There was a significant effect of 0.2% brimonidine tartrate in the prevention of IOP elevation in PACG patients previously found to test positive in the dark-prone provocative test.
Dr. P.T. Hung, Department of Ophthalmology, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, Taiwan. portying@ha.mc.ntu.edu.tw
Classification:
11.3.3 Apraclonidine, brimonidine (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
