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Abstract #3618 Published in IGR 4-2
Effect of betaxolol on impaired choroidal blood flow after intravitreal injection of endothelin-1 in albino rabbits
Kim JH; Kim DM; Park WCJournal of Ocular Pharmacology and Therapeutics 2002; 18: 203-209
The authors investigated the effect of topical betaxolol on impaired choroidal blood flow (CBF) induced by endothelin-1 (ET-1) injection into the vitreous of albino rabbits. Betaxolol (n = 7) or balanced salt solution (BSS) (n = 6) was instilled in the right eyes before and 12 hours after the intravitreal injection of ET-1 (10-6 M, 10 μl), and BSS was instilled in the right eyes before and 12 hours after the intravitreal injection of BSS (n = 6). Blood pressure, intraocular pressure (IOP) and CBF were measured prior to the instillation of betaxolol or BSS, and just before and two, 12 and 24 hours after ET-1 or BSS injection. CBF was measured by scanning laser Doppler flowmetry. Intravitreal injection of ET-1 decreased CBF. Compared with topical BSS, topical betaxolol significantly inhibited the decrease in CBF at two hours (p = 0.022), 12 hours (p = 0.046) and 24 hours (p = 0.015) after the intravitreal injection of ET-1. There was no significant change of blood pressure or IOP after the topical administration of betaxolol or the intravitreal injection of ET-1. The decrease in CBF after the intravitreal injection of ET-1 was partially inhibited by topical betaxolol.
Dr. J.H. Kim, Department of Ophthalmology, Seoul National University Hospital, 28 Yongon-Dong, Chongno-Gu, Seoul 110-744, South Korea. dmkim@snu.ac.kr
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
