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1 General aspects (0)   1.1 Epidemiology (14)   1.2 Population genetics (0)   1.3 Pathogenesis (2)   1.4 Quality of life (11)   1.5 Glaucomas as cause of blindness (10)   1.6 Prevention and screening (13) 2 Anatomical structures in glaucoma (0)   2.1 Conjunctiva (12)   2.2 Cornea (30)   2.3 Sclera (2)   2.4 Anterior chamber angle (8)   2.5 Meshwork (0)     2.5.1 Trabecular meshwork (17)     2.5.2 Schlemms canal (1)     2.5.3 Scleral outlet channels (2)   2.6 Aqueous humor dynamics (0)     2.6.1 Production (0)     2.6.2 Outflow (0)       2.6.2.1 Trabecular meshwork (5)       2.6.2.2 Uveoscleral (1)     2.6.3 Compostion (3)   2.7 Episcleral veins and venous pressure (4)   2.8 Iris (5)   2.9 Ciliary body (5)   2.10 Lens (0)   2.11 Vitreous body (0)   2.12 Choroid, peripapillary choroid, peripapillary atrophy (7)   2.13 Retina and retinal nerve fibre layer (30)   2.14 Optic disc (28)   2.15 Optic nerve (2)   2.16 Chiasma and retrochiasmal central nervous system (6)   2.17 Stem cells (1)   2.20 Other (0) 3 Laboratory methods (0)   3.1 Microscopy (3)   3.2 Electron microscopy (0)   3.3 Immunohistochemistry (6)   3.4 Molecular genetics (0)     3.4.1 Linkage studies (3)     3.4.2 Gene studies (39)   3.5 Molecular biology incl. 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pharmacoeconomics (4) 15 Miscellaneous (37)

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Abstract #45520 Published in IGR 13-2

Contact transcleral photodynamic cyclo-suppression in human eyes: a feasibility study

Charisis SK; Detorakis ET; Vitanova VS; Panteleontidis VA; Kounis GA; Tsilimbaris MK
Canadian Journal of Ophthalmology 2010; 46: 196-198

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Objective: To evaluate the safety and efficacy of contact transcleral ciliary body photodynamic treatment (CB-PDT) with verteporfin in human eyes. Design: Prospective interventional case series. Participants: Five glaucomatous blind eyes of 5 patients. Methods: Verteporfin (6 mg/m2) was infused in bolus and then the ciliary body was irradiated transclerally with a fibre optic device. Twelve spots were placed 360u and 0.5 mm behind the sclerocorneal limbus. Laser power was 80 mW and irradiation time was 3 minutes. Results: The average intraocular pressure reduction was 30% after the first month and remained below pre-treatment levels throughout a 3-month follow-up. No serious adverse events were reported. Conclusions: CB-PDT for refractory glaucoma was safe and efficient in human eyes; larger studies are required to evaluate its possible clinical role.

University Hospital of Heraklion, Department of Ophthalmology, Crete, Greece.

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Classification:

12.10 Cyclodestruction (Part of: 12 Surgical treatment)

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