advertisement
Abstract #45603 Published in IGR 13-2
Young age as a risk factor for complicated course and visual outcome in intermediate uveitis in children
Kalinina Ayuso V; Ten Cate HAT; Van Den Does P; Rothova A; de Boer JHBritish Journal of Ophthalmology 2011; 95: 646-651
Objective: To identify prognostic factors in intermediate uveitis (IU) in children. Methods: Retrospective case series of 35 patients with onset of IU (less-than or equal to)16 years and a minimum follow-up of 1 year. Demographic and numerous clinical data were documented. Visual outcomes and development of complications were analysed in relation to age of onset and ocular signs at presentation. Results: Forty-six per cent of patients had onset (less-than or equal to)7 years, and 54% >7 years. The younger-onset group had a shorter event-free survival for secondary glaucoma (p=0.04) and vitreous haemorrhage (p=0.01). The mean age of onset in children with cataract (5.9 vs 8.7 years), glaucoma (5.0 vs 8.4) and vitreous haemorrhage (5.6 vs 8.5) was lower than in children without these complications (all p=0.03). Frequencies of other complications did not differ between both groups. The younger-onset group had worse BCVAs at presentation (0.3 vs 0.6), at 1 year (0.4 vs 0.9) and at 3 years' follow-up (0.6 vs 0.9; all p(less-than or equal to)0.04), and they needed longer treatment (p=0.01). Children with young onset of IU reached remission less frequently (p=0.05). Development of cystoid macular oedema was independently associated with papillitis (adjusted HR=3.4; p=0.02) and snowbanking (adjusted HR=3.3; p=0.03) at presentation. Other complications at onset were not predictive for future complications. Conclusions: Children with young onset of IU carry a higher risk of complications and worse visual outcome. The authors would recommend considering more intensive monitoring and earlier threshold for systemic treatment in those children with risk factors as early onset, papillitis and/or snowbanking at initial presentation.
V. Kalinina Ayuso. Department of Ophthalmology, University Medical Center Utrecht, Postbus 85500, 3508 CX Utrecht, Netherlands. Email: v.kalininaayuso@umcutrecht.nl
Classification:
9.4.6 Glaucomas associated with inflammation, uveitis (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
9.1.2 Juvenile glaucoma (Part of: 9 Clinical forms of glaucomas > 9.1 Developmental glaucomas)